Volume 5, Issue 3, September 2020, Page: 18-23
Epilepsy and Depression, Comorbidity Problems of Treatment Tactics
Nadir Aliyev, Department of Psychiatry and Drug Addiction, Azerbaijan State Advanced Training Institute for Doctors Named by A. Aliyev, Baku, Azerbaijan Republic
Zafar Aliyev, Departments of Psychiatry, Azerbaijan Medical State University, Baku City, Azerbaijan Republic
Received: Aug. 14, 2020;       Accepted: Aug. 24, 2020;       Published: Sep. 21, 2020
DOI: 10.11648/j.rs.20200503.11      View  53      Downloads  20
Objective: Despite the availability of literary data on the treatment of comorbidity of epilepsy and depression, their therapy has not been fully resolved. However, epilepsy and depression are often combined. Materials and Methods: The aim of the study was development therapy in the comorbidity of epilepsy and depression in adults. The study included 100 patients with epilepsy. The severity of depression was studied by using the Hamilton scale, ICD-10 and DSM-5 criterions. Patients were observed at the Mental Health Center of the Ministry of Health of the Republic of Azerbaijan from January 2018 to January 2020 for 24 months. Patients took standard antiepileptic drugs (depakin-chrono 1000 mg/day, lamotrigine 150 mg/day, levitracetam 3000 mg/day) and antidepressant drug-citalopram was taken 10 mg twice a day, in the morning and in the evening. Results: Depression of varying severity was detected in 70 % of the examined patients 10 cases of mild, 40 moderate and 20 case of severe depression without psychotic symptoms. Conclusion: The combination of anticonvulsants with antidepressants Citalopram 10 mg in morning and evening (per os) reduces the frequency of seizures and reduces the severity of depression. The study of comorbidity of epilepsy and depression is of great theoretical and practical importance. First, it will contribute to the early detection of depression. Second, prevent suicides. Third, it will help reduce refractory epilepsy. Finally, improve their quality of life for patients with epilepsy.
Epilepsy, Depression, Comorbidity, Treatment
To cite this article
Nadir Aliyev, Zafar Aliyev, Epilepsy and Depression, Comorbidity Problems of Treatment Tactics, Rehabilitation Science. Vol. 5, No. 3, 2020, pp. 18-23. doi: 10.11648/j.rs.20200503.11
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Hippocrates, The Sacred Disease, vol. 2, Loeb Classical Library and Harvard University Press, London, UK, 1965, translated by W. H. S. Jones.
Neurological Disorders: Public Health Challenge (2010) Global Burden of Neurological Disorders, World Health Organization.
Wolf P (2003) Praxisbuch Epilepsien. Diagnostik, Behandlung, Rehabilitation-Kohlhammer, Stuttgart 394.
Kanner AM (2006) Depression and epilepsy: a new perspective on two closely related disorders. Epilepsy Curr 6: 141-146. [Crossref].
Kanner AM (2007) Epilepsy and mood disorders. Epilepsia 48 Suppl 9: 20-22.
Kanner AM (2008) Depression in epilepsy: a complex relation with unexpected consequences. Curr Opin Neurol 21: 190-194. [Crossref].
Mula M, Schmitz B, Sander JW (2008) The pharmacological treatment of depression in adults with epilepsy. Expert Opin Pharmacother 9: 3159-3168. [Crossref] Mula M1, Hesdorffer DC (2011) Suicidal behavior and antiepileptic drugs in epilepsy: analysis of the emerging evidence. Drug Healthc Patient Saf 3: 15-20. [Crossref].
Aliyev NA, Aliyev ZN, Aliyeva SE (2018) Selective neuronal potassium channel opener (SNEPCO) flupirtine in treatment-resistant epilepsy comorbid depression in adults. Ment Health Addict Res 3: 4-5].
Zimmerman M Martinez JH Young D Chelminski I Dalrymple K. Severity classification on the Hamilton Depression Rating Scale. J Affect Disord 2013; 150: 384–388. Google Scholar Crossref PubMed.
Gilliam F, Hecimovic H, Sheline Y (2003) Psychiatric comorbidity, health, and function in epilepsy. Epilepsy Behav 4: 26-30. [Crossref].
Fiest KM, Dykeman J, Patten SB, Wiebe S, Kaplan GG, et al. (2013) Depression in epilepsy a systematic review and meta-analysis. Neurology 80: 590-599. [Crossref].
Kupfer DJ, Frank E, Phillips ML (2012) Major depressive disorder: new clinical, neurobiological, and treatment perspectives. The Lancet 379: 1045-1055. [Crossref].
Victoroff JI, Benson F, Grafton ST, Engel J Jr, Mazziotta JC (1994) Depression in complex partial seizures. Electroencephalography and cerebral metabolic correlates. Arch Neurol 51: 155-163. [Crossref].
Kanner AM, Schachter SC, Barry JJ, Hersdorffer DC, Mula M, et al. (2012) Depression and epilepsy: epidemiologic and neurobiologic perspectives that may explain their high comorbid occurrence. Epilepsy Behav 24: 156-168. [Crossref].
Swinkels J WAM, Kuyk EH de Graaf, van Dyck R, Ph Spinhoven (2001) Prevalence of Psychopathology in Dutch Epilepsy Inpatients: A Comparative Study. Epilepsy Behav 2: 441-447. [Crossref].
Jackson MJ, Turkington D. Depression and anxiety in epilepsy. J Neurol Neurosurg Psychiatry 2005; 76 (suppl 1): 45-7.
Gaitatzis A, Trimble MR, Sander JW. The psychiatric comorbidity of epilepsy. Acta Neurol Scand 2004; 110 (4): 207-20.
Harden CL1, Goldstein MA (2002) Mood disorders in patients with epilepsy: epidemiology and management. CNS Drugs 16: 291-302. [Crossref].
Jones JE, Hermann BP, Woodard JL, Barry JJ, Gilliam F, et al. (2005) Screening for major depression in epilepsy with common self-report depression inventories. Epilepsia 46: 731-735. [Crossref].
Gilliam FG. Diagnosis and treatment of mood disorders in persons with epilepsy. Curr Opin Neurol 2005; 18 (2): 129-33.
Mazarati A, Siddarth P, Baldwin RA, Shin D, Caplan R, Sankar R. Depression after status epilepticus: behavioural and biochemical deficits and effects of fluoxetine. Brain, 2008, 131 (8): 2071–8.
Mehndiratta P, Sajatovic M. Treatments for patients with comorbid epilepsy and depres-sion: a systematic literature review. Epilepsy Behav, 2013, 28 (1): 36–40. 9, 27.
Koh S, Magid R, Chung H, Stine CD, Wilson DN. Depressive behavior and selective down-regu-lation of serotonin receptor expression after early-life seizures: reversal by environmental enrichment. Epilepsy Behav 2007, 10 (1): 26-31; 26.
Woif P. Praxisbuch Epilepsien. Diagnostik, Behandlung, Rehabilitation. Kohlhammer, Stuttgart, 2003. p. 394.
Kanner A. M., Ramses Ribot R. and Mazarati A. Bidirectional relations among common psychiatric and neurologic comorbidities and epilepsy: Do they have an impact on the course of the seizure disorder? Epilepsia Open, 3 (s2): 210–219, 2018 doi: 10.1002/epi4.12278.
Usyukina M. V. Phenomenology and therapy of affective disorders in epilepsia. Meditsinskiy sovet=Medical Council. 2018; (1): 64-69. (In Russ.) https://doi.org/10.21518/2079-701X-2018-1-64-69.
De Lima C, de Lira CA, Arida RM, Andersen ML, Matos G, de Figueiredo Ferreira Guilhoto LM et al. Association between leisure time, physical activity, and mood disorder levels in individuals with epilepsy. Epilepsy Behav, 2013, 28 (1): 47-51.
Kimiskidis VK, Triantafyllou NI, Kararizou E, Gatzonis SS, Fountoulakis KN, Siatouni A et al. Depression and anxiety in epilepsy: the associ-ation with demographic and seizure-related variables. Ann. Gen. Psychiatry., 2007, 6: 2.
Ribot R, Ouyang B, Kanner AM. The impact of anti-depressants on seizure frequency and depressive and anxietydisorders of patients with epilepsy: Is it worth investigating? Epilepsy Behav, 2017 May, 70.
Mula M. Epilepsy and depression: An update. Arch Med Health Sci 2019; Volume. 7; Issue 1 P. 104‑111.
McConnell H, Duncan D. Treatment of psychiatric comorbidity in epilepsy. In: McConnell HW, Snyder PJ, eds. Psychiatric comorbidity in epilepsy: basic mechanisms, diagnosis, and treatment. Washington DC: American Psychiatric Publishing; 1998: 245-361.
Barry JJ. The recognition and management of mood disorders as a comorbidity of epilepsy. Epilepsia 2003; 44 (suppl 4): 30-40.
Post R. M. Do the epilepsies, pain syndromes, and affective disorders share common kindling-like mechanisms? Epilepsy Research 50 (2002) P. 203-219.
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